Mumakore ekuma1990, Pfizer akatungamira mukugadzira uye kunyora pasi yekutanga isiri-gelatin capsule shell product, iyo huru mbishi inova cellulose ester "hydroxypropyl methyl cellulose" kubva muzvirimwa.Nekuti iyi mhando nyowani yecapsule haina chero mhuka yezvigadzirwa, inorumbidzwa neindasitiri se "plant capsule".Parizvino, kunyangwe huwandu hwekutengesa kwezvirimwa capsules mumusika wepasi rose wecapsule hauna kukwirira, kusimudzira kwayo kwakasimba, ine nzvimbo yakakura yekukura kwemusika.
　　
"Nekuvandudzwa kwesayenzi yezvokurapa uye teknolojia uye sainzi yakabatana, kukosha kwemishonga yemishonga mukugadzirwa kwemishonga yemishonga yakave ichizivikanwa zvishoma nezvishoma, uye chimiro chemishonga chiri kuwedzera."Ouyang Jingfeng, mubatsiri wemuongorori paChinese Academy yeChinese Medical Sayenzi, akataura kuti vabatsiri vemishonga havangotarise mhando yemafomu matsva emushonga uye kugadzirira kutsva kwemishonga kusvika pamwero mukuru, asi zvakare kubatsira kugadzirira kuumba, kudzikamisa, kunyungudika. , wedzera solubilize, wedzera kusunungurwa, kusunungurwa kwakasimba, kusunungurwa kunodzorwa, kutarisa, nguva, nzvimbo, kukurumidza-kuita, inobudirira uye yakareba-kuita, uye neimwe nzira, kuvandudzwa kwemubatsiri mutsva wakanakisisa kunogona kutungamirira kukuvandudzwa kwekirasi huru. yemafomu emushonga, kunatsiridza kunaka kwenhamba huru yemishonga mitsva uye magadzirirwo, uye kukosha kwayo kunopfuura nekure kugadzirwa kwemushonga mutsva.Mumhando yemishonga yemishonga yakadai semapiritsi ekrimu, mahwendefa, majekiseni, uye capsules, capsules dzave nzira huru dzeyero yemishonga yakasimba yemuromo nekuda kwepamusoro-soro yebioavailability, kuvandudza kugadzikana kwemishonga, uye nguva yakatarwa uye kusunungurwa kwemishonga.

Parizvino, iyo huru mbishi yekugadzirwa kwemakapisi ndeyegelatin, gelatin inogadzirwa nehydrolysis yemapfupa emhuka nematehwe, uye ndeye biological macromolecule ine ternary spiral chimiro, ine yakanaka biocompatibility uye yemuviri nemakemikari zvinhu.Nekudaro, gelatin capsules zvakare ine zvimwe zvinogumira mukushandisa, uye kugadzirwa kwezvinhu zvitsva zvemakapule shells asiri emhuka kwave nzvimbo inopisa mukutsvagisa kuchangobva kuitika kwemishonga yemishonga.Wu Zhenghong, purofesa paChina Pharmaceutical University, akataura kuti nekuda kwe "chirwere chemombe" munyika dzeEurope dzakadai seBritain, France neNetherlands kuma1990s (kusanganisira Japan muAsia, iyo yakawanawo mhou dzinopenga dzine chirwere chemombe) , vanhu vomunyika dzokuMadokero vakanga vasingavimbi nenyama yemombe uye mombe dzine chokuita nezvibereko (gelatin imwe yachowo).Uye zvakare, maBhudha nevanodya zvinomera zvakare vanopokana negelatin capsules akagadzirwa kubva kumhuka mbishi zvinhu.Tichifunga izvi, mamwe makambani ekune dzimwe nyika emakapule akatanga kudzidza zvinhu zvitsva zve capsule shells yeasiri-gelatin uye mamwe masosi emhuka, uye hutongi hwechinyakare gelatin capsules hwakatanga kuzununguka.

Kutsvaga zvinyowani zvekugadzirira zvisiri-gelatin capsules ndiyo yazvino kutungamira kutungamira kwezvemishonga excipient.Ouyang Jingfeng akataura kuti zvigadzirwa zvemiti capsules parizvino hydroxypropyl methylcellulose, modified starch uye mamwe hydrophilic polymer chikafu glues, senge gelatin, carrageenan, xanthan chingamu uye zvichingodaro.Hydroxypropyl methyl cellulose capsules ine solubility yakafanana, disintegration uye bioavailability kune gelatin capsules, nepo iine zvimwe zvakanakira izvo gelatin capsules haina, asi iko kushandiswa kwazvino hakusati kwakanyanyisa, kunyanya nekuda kwemutengo wepamusoro wechigadzirwa, zvichienzaniswa negelatin. hydroxypropyl methyl cellulose capsule raw material mutengo wakakwira, mukuwedzera kune inononoka gel kumhanya, zvichikonzera kureba kwekugadzira kutenderera.

Mumusika wepasi rose wemishonga, zvidyarwa capsules ndechimwe chezvinhu zvinokurumidza kukura zvigadzirwa.Wu Zhenghong akataura kuti zvichienzaniswa negelatin capsules, macapsules echirimwa ane zvinotevera zviri pachena zvakanakira: Chekutanga, hapana maitiro ekubatanidza.Plant capsules ine inertness yakasimba uye haisi nyore kuyambuka nemapoka ealdehyde kana mamwe makomisheni.Yechipiri inokodzera mishonga isinganzwisisi mvura.Kunyorova kwechirimwa capsules kunowanzo kudzorwa pakati pe5% ne8%, uye hazvisi nyore kuita zvemakemikari nezviri mukati, uye iyo yakaderera yemvura inovimbisa kugadzikana kweiyo hygroscopic zvirimo zvinotapukirwa nekunyorova.Yechitatu ndeyekuenderana kwakanaka neiyo huru yemishonga excipients.Vegetable capsules vane kugarisana kwakanaka nelactose, dextrin, starch, microcrystalline cellulose, magnesium stearate uye zvimwe zvikuru zvinowanzo shandiswa mishonga excipients.Yechina ndeyekuva nenzvimbo yakasununguka yekuzadza.Plant capsules ine zvakasununguka zvinodiwa zvenzvimbo yekushanda yezvakazadzwa zviri mukati, zvingave izvo zvinodiwa zvenzvimbo yekushanda kana chiyero chekupasa pamushini, izvo zvinogona kuderedza mutengo wekushandisa.
　
　
"Munyika, macapsules emiti achiri muhucheche, mabhizimisi mashomanana chete anogona kubudisa mishonga yemiti yemiti, uye zvakakosha kuwedzera kusimbisa tsvakurudzo mumagadzirirwo ekugadzira uye zvimwe zvinhu, uyewo kuwedzera kuedza kwekusimudzira misika."Ouyang Jingfeng akataura kuti pari zvino, kubuda kwegelatin capsules muChina kwasvika panzvimbo yekutanga pasirese, nepo chikamu chemusika chezvirimwa capsule zvigadzirwa zvichiri kuderera.Uye zvakare, nekuti iyo nzira yekugadzira macapsules haina kushanduka kweanopfuura makore zana, uye kuenderera mberi kwekuvandudza kwemidziyo kunogadzirwa zvinoenderana nekugadzirwa kwegelatin, mashandisiro ekushandisa uye midziyo yekugadzira gelatin capsules kugadzira chirimwa. capsules yave yakatarisana nekutsvagisa, iyo inosanganisira iyo chaiyo yekudzidza yemaitiro zvinhu senge viscosity, rheological zvimiro uye viscoelasticity yezvinhu.
　　

Kunyangwe zvisingaite kuti macapsules echirimwa atsive hutongi hwechinyakare gelatin hollow capsules, chirimwa macapsules ane zviri pachena makwikwi mabhenefiti muChinese yechinyakare mishonga yekuChina kugadzirira, biological gadziriro uye zvinoshanda chikafu.Zhang Youde, mainjiniya mukuru paChikoro cheZvishandiso Sainzi neUinjiniya cheBeijing Institute of Technology, anotenda kuti nekunzwisisa kwakadzama kwevanhu kwemakapisi ezvirimwa uye shanduko yepfungwa yemishonga yeveruzhinji, kudiwa kwemusika kwemakapisi ezvirimwa kuchakura nekukurumidza.